Sedaris will portray a "successful therapist named Dr Jane Crosetti, who goes toe-to-toe with Callie Thorne's Dani", reports Entertainment Weekly.
The Strangers with Candy star will appear on the sixth episode of the second season, which will premiere on June 6 on USA.
Necessary Roughness centres on Dani, a divorcee who becomes a therapist for a professional football team to make money.
Sedaris has guest starred in several television shows such as The Good Wife, Raising Hope, The Closer and Hot in Cleveland.
The actress is also an author, having published New York Times best-seller I Like You: Hospitality Under The Influence in 2006.
Watch a trailer for Necessary Roughness's first season below: