Bent, Are You There, Chelsea? and Best Friends Forever have also been axed.
Jason Isaacs's Awake, about a detective who finds himself living out two realities, received rave reviews for its pilot earlier this year, but the show has struggled in the ratings for NBC.
Talking about the show in 2011, Isaacs described it as "a risk" for network TV.
It was reported last month that the first season will be shown on Sky Atlantic.
Prior to the cancellation of Best Friends Forever, NBC pulled the first season of the comedy from its schedule at the end of April.