The series, based on the Dutch show Penoza, focuses on a housewife who is forced to enter the world of organised crime following the murder of her husband.
Radha Mitchell will play the lead role of Marta, who discovers that her late husband's business partners were involved in an illegal drug business deal which led to his killing.
Marta is soon forced to take on both gangsters and the FBI to find out more about the death of her husband.
Wil Traval, Lee Tergesen, Rade Sherbedzija, Luke Goss, Jaime Ray Newman and Mido Hamada are among the other stars who will appear in Red Widow.
Watch a trailer for Red Widow below: