In the clip from Joel McHale's weekly series on E!, the True Blood star stops by to promote his stripper movie Magic Mike, but fails to realise that he no longer has the impressive abs he once had.
Instead, Manganiello sports a fake beer belly and a six-pack of beer.
"Joe, you look a little different than you do in Magic Mike," McHale says to Manganiello.
"Well yeah, the camera adds 15 pounds, Joel. There's nothing you can do about it," he responds.
At the end of the video, Minogue joins Manganiello to eat Doritos off his stomach.
"Don't mind them," McHale says. "They're just trying to break the internet."
Last month, the 35-year-old described himself as "too healthy" for Hollywood, claiming that his impressive physique was considered to be too imposing for movie roles.
The Soup airs Wednesdays at 10pm on E!.
Watch Kylie Minogue and Joe Manganiello on The Soup below: