The British rock star-turned-actor will play a one-hit wonder from the 1970s who spent all his earnings and has been skirting creditors ever since, reports TVLine.
The MacGyver star will make his debut on the third episode of season ten, which will premiere on Tuesday, September 25 on CBS.
NCIS showrunner Greg Glasberg shared: "This is a very fun episode and Michael Des Barres brings tremendous humour and idiosyncrasy to a character he knows oh-too-well. We really lucked out having him join us."
Des Barres was the vocalist of the rock band Detective, which was formed in 1975 but disbanded three years later.
He has since joined other bands as well as releasing solo albums.
Des Barres's acting credits include Mulholland Dr, Alias, Bones and Suits.
Watch a clip of NCIS below: