The Girls Aloud singer and former X Factor judge is said to be a top target for the ABC show's producers, according to The Mirror.
"They really want to get Cheryl involved, and it's a coveted slot," an insider at the network claimed. "Everyone from Britney Spears to Lady GaGa have made it known that they would love to appear in it.
"It's a real honour to be asked to do it, and it would be a great next step after Cheryl's appearance in What To Expect When You're Expecting. And it would be a massive dig at The X Factor USA."
Modern Family has won top prizes at the Primetime Emmys and Golden Globes in the past year, and counts US president Barack Obama and his family among its famous fans.
Cole will make a cameo appearance in What To Expect When You're Expecting - which is due for release in the UK and US next month - playing a talent show judge.
Her comeback single 'Call My Name' is due to debut on UK national radio later this morning (April 20).
Watch a trailer for What To Expect When You're Expecting below:
Picture gallery - Cheryl Cole through the years: