GaGa will guest star as herself in the season finale of The Simpsons on May 20. GaGa will help Lisa Simpson after her plans to become popular backfire.
Blanchett will lend her vocal talents to Family Guy on April 30. Blanchett will voice a female character who becomes the object of Stewie's (Seth MacFarlane) affection.
Other noted celebrity guests include The View's Whoopi Goldberg as a dean on Glee, while Justin Long will return on New Girl on May 1, and singer Fergie, Rashida Jones and Glee's Darren Criss will lend their voices to The Cleveland Show on April 29.
The month of May will also see the conclusion of Fox show House, with a special two-hour series finale event on May 21.
Meanwhile, McKinley High's class of 2012 will graduate when Glee airs its season three finale on May 22.
American Idol will also crown the winner for season 11 on May 23.
Watch a preview video of Lady GaGa on The Simpsons below: