The actress, who played reckless socialite Marissa Cooper in the series, said that things got "a bit out of control" because of the show and harmed society as a result.
Barton told Fearne Cotton: "As fun as it was and cool as it was, it spawned all these reality TV shows like The Real O.C. and The Real Laguna or whatever.
"That's gotten a bit out of control… For me, it's a bit funny because I feel like I almost aided the problem for young girls and for that genre."
When Fearne Met Mischa airs tonight at 8pm on ITV2.