Falchuk told TVLine that Blaine (Darren Criss), Brittany (Heather Morris) and Tina (Jenna Ushkowitz) will sing the Carly Rae Jepsen hit.
Lea Michele (Rachel) and new cast member Melissa Benoist (Marley) will also duet on a version of Billy Joel ballad 'New York State of Mind', the exec producer confirmed.
"It's a really beautiful number," he promised, adding that the song will feature in one of season four's early episodes.
It was recently announced that Whoopi Goldberg will reprise her role as the Dean of performance school NYADA in the Fox musical's new season.
Glee will return for its season four premiere - titled 'The New Rachel' - on September 13 on Fox. In the UK, the series airs on Sky1.
> 'Glee' execs teases season four break-ups: 'It'll be tough'
> 'Glee': Kate Hudson stars in season four promo - video
Watch the video for Carly Rae Jepsen's 'Call Me Maybe' below: