The actress, who chose to quit the show in May, said that she felt like it was time to move on from the medical drama.
"It was very sad and very disappointing and a really difficult decision to make," Edelstein told TV Line. "But ultimately I felt like it was the best thing for me to do for myself and for my business. I'm really looking forward to some of the great things I have on my plate right now. That's pretty much what I'm focusing on."
Edelstein went on to reveal that she is excited by the new opportunities that are coming her way since leaving the Fox series.
"It's interesting to throw yourself back out there into the world after you've had such an amazing job after seven years," Edelstein explained. "You get cushy about it, and you lay back and you let yourself be taken care of for a while. And having to get your hustle back on is both terrifying and really exciting."
House star Hugh Laurie recently insisted that the actress is missed on the medical drama. However, Edelstein does not believe that she will return to the series in the future.
"I haven't talked to anyone over there so [a return] would seem unlikely," Edelstein said. "Who knows what I'll be doing? I have a lot on my plate. I wouldn't want to... get anyone's hopes up. It doesn't seem like that's the direction anyone is going in."
In June, it was announced that Edelstein had joined The Good Wife for a multi-episode arc.