The image features Hugh Laurie's eponymous character snapping his trademark cane in front of the words "the end".
House's final episode, entitled 'Everybody Dies', is set to air on Fox on May 21.
Commenting on the name, House producer David Shore explained: "It's fundamentally true, and it's also a nice reflection on the name of the pilot, which was 'Everybody Lies'.
"It'll become clearer as we get closer to [the finale] what's going on. But it's certainly House assessing his life, and his future."
Former House stars Olivia Wilde (Remy 'Thirteen' Hadley) and Amber Tamblyn (Martha Masters) have been confirmed to return for the finale, while Kal Penn is rumoured to be appearing as deceased character Lawrence Kutner.
The eighth and final season of House airs 9/8c on Fox. UK viewers can catch it Thursdays at 10pm on Sky1.
Watch the House team discuss the series finale below: