Safran revealed that he wants the duo, played by Matthew Settle and Kelly Rutherford, to have a good relationship in upcoming episodes.
"We really don't want to mess with that couple," he told E! Online. "We really believe that they worked really hard to get together."
However, Safran suggested that the news could signal fewer storylines based around the couple in the future.
"I think that might mean less single, standalone stories for them," he said. "But that's because we want them to be grounded, together and intact so they fold into people's stories as opposed to having their own definable arcs."
Gossip Girl airs on Mondays at 8/7c on The CW in the US. The fifth season will premiere in the UK on Wednesday, October 19 at 8pm on ITV2.
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